Why Supplement Collagen

More than 50% of the main structural protein of the skin is collagen, and collagen is the most important structure in human skin tissue. As we age, the rate of collagen loss in the human body is much greater than the rate of its synthesis. Dr. Brandt, the father of collagen in the world, once said that “the aging process of skin is the process of collagen loss.” To stay young, it is imperative to replenish collagen.

What are the ways to supplement collagen?

1. Food supplements : eat pig’s trotters, bird’s nest, fish, beans, etc. The molecular weight of collagen in food ranges from 100,000 to 300,000.

2. Medical aesthetics , directly replenishing collagen through subcutaneous injection.

3. For external skin care products , it is difficult for smear-on collagen to penetrate the dermal layer of the skin. The molecular weight of smear-on skin care products ranges from several thousand to tens of thousands.

4. Collagen peptide oral solution . Most of the collagen peptides can be directly absorbed by the human body. The molecular weight of Collagen Peptide Oral Solution is < 5000 Da.

The molecular weight of collagen in food is too large and can hardly be absorbed by the human body. The collagen in skin care products has difficulty penetrating the dermis. Medical aesthetics has good results but high risks and low safety. In contrast, collagen peptide oral liquid is highly safe, has a small molecular weight, and most of it can be directly absorbed by the human body. Collagen peptide oral solution is a safe and effective way to supplement collagen.

How should I choose among the collagen peptide drinks on the market?

1.Pay attention to absorption rate

2.Pay attention to utilization

3.Pay attention to the effect

What are collagen peptides?

Collagen peptides are small molecule active peptides formed from collagen extracted from fish skin or fish scales after enzymatic hydrolysis. On the basis of collagen peptides, collagen tripeptides, a small molecule tripeptide composed of 3-5 amino acid residues and more easily absorbed by the human body, are decomposed.

The absorption rate of collagen tripeptide is higher than that of general collagen peptides.

General collagen peptides need to be decomposed first after entering the human body before they can form collagen tripeptides for the skin. Collagen tripeptide does not need to be broken down when entering the human body, and can directly reach the dermis.

The higher the collagen tripeptide content, the higher the human body’s absorption rate.

Human clinical data shows that compared with collagen and collagen peptides, collagen tripeptides are more easily absorbed and utilized by humans.

The above figure is the average molecular weight of the three samples used in the experiment and the peptide content of the three samples. The average molecular weight of CTP-100 is about 300Da, and the tripeptide content accounts for about 92%, without polypeptides. The average molecular weight of CTP-50 is approximately 600 Da, of which the tripeptide content accounts for approximately 51%. CP samples have a broad distribution of molecular weights with an average of approximately 5000 Da.

The picture above shows that after oral administration of collagen peptides for 60 minutes, the CTP-100 content in the blood was the highest, followed by CTP-50, and the CP content remained almost unchanged. The results show that collagen peptides with small molecular weight have high absorption rates, and the average molecular weight of collagen tripeptide is <500Da.

Collagen tripeptide utilization rate is higher

Collagen tripeptide not only has a high absorption rate, but also a high utilization rate. Collagen peptides are not as small as possible. Our ultimate goal is to make the skin synthesize collagen. No matter how high the absorption rate is, it is useless if it cannot synthesize collagen. Studies have shown that 100 minutes after taking dipeptides and tripeptides, the amount of tripeptide molecules transported in the plasma is significantly higher than that of dipeptide molecules. This shows that the tripeptide used to synthesize collagen is more active and has a higher utilization rate than the dipeptide.

This is because the specific Gly-Pro-Hyp structure of collagen tripeptide is used directly to synthesize collagen. While ensuring the absorption rate, it also ensures the utilization rate.

The more types of protein peptides, the better the effect

The more types of peptides and the more complete their functions, the better the effect will be. According to the different functions of collagen in the human body, collagen is divided into 28 types, as follows:

Different peptides have different functions. The combination of peptides with different functions has a more comprehensive effect and better effects. For example, peptides responsible for connecting the epidermis and dermis work together with structural collagen peptides to more effectively improve skin condition. Most of the collagen peptide products currently on the market are type I, type III peptides, or a single type of peptide. But different peptides have different functions. The more types of peptides there are, the more complete the functions and the better the effect. When choosing a collagen peptide drink, you should give priority to a protein peptide drink with more peptide types and more comprehensive functions, so that the effect will be better. When supplementing collagen, you can choose a collagen peptide drink whose raw material is collagen tripeptide, which is safe and effective.

references:

1. Yamamoto S, Deguchi K, Onuma M, et al. Absorption and urinary excretion of peptides after collagen tripeptide ingestion in humans[J]. Biological and Pharmaceutical Bulletin, 2016, 39(3): 428-434.

2. Sneha B. Sontakke, Jin-hee Jung, Zhe Piao, and Hye Jin Chung. Orally Available Collagen Tripeptide: Enzymatic Stability, Intestinal Permeability, and Absorption of Gly-Pro-Hyp and Pro-Hyp

Journal of Agricultural and Food Chemistry 2016 64 (38), 7127-7133     DOI: 10.1021/acs.jafc.6b02955